| 4. Ronde | 05.02.2022 | CF América [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 5. Ronde | 12.02.2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 4:1 | ||||
| 6. Ronde | 19.02.2022 | UANL Tigres [U20] | - | Atlético San Luis [U20] | 1:1 | ||||
| 7. Ronde | 26.02.2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 8. Ronde | 02.03.2022 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 2:3 | ||||
| 9. Ronde | 06.04.2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 |  |
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| 13. Ronde | 09.04.2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:1 |  |
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| 14. Ronde | 15.04.2022 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 15. Ronde | 20.04.2022 | Atlético San Luis [U20] | - | Pumas UNAM [U20] | 2:1 | |
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| 16. Ronde | 24.04.2022 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 2:2 | ||||
| 17. Ronde | 01.05.2022 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 2:2 | |
Mexico
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