| 1. Ronde | 23.07.2021 | Club Necaxa [U18] | - | Santos Laguna [U18] | 3:1 |  |
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| 3. Ronde | 07.08.2021 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | ||||
| 4. Ronde | 15.08.2021 | Santos Laguna [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 5. Ronde | 18.08.2021 | Santos Laguna [U18] | - | Atlas Guadalajara [U18] | 2:3 | ||||
| 6. Ronde | 21.08.2021 | Club León [U18] | - | Santos Laguna [U18] | 3:1 |  |
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| 7. Ronde | 29.08.2021 | Santos Laguna [U18] | - | FC Juárez [U18] | 0:0 | ||||
| 8. Ronde | 10.09.2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 12. Ronde | 02.10.2021 | Santos Laguna [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 13. Ronde | 16.10.2021 | CF Pachuca [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 15. Ronde | 24.10.2021 | Santos Laguna [U18] | - | Deportivo Toluca [U18] | 3:1 | ||||
| 16. Ronde | 30.10.2021 | Gallos Blancos [U18] | - | Santos Laguna [U18] | 1:1 | ||||
| 11. Ronde | 04.11.2021 | Pumas UNAM [U18] | - | Santos Laguna [U18] | 0:1 |
Mexico