| 3. Ronde | 23.01.2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 10. Ronde | 12.03.2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 12. Ronde | 03.04.2022 | Santos Laguna [U18] | - | CF Pachuca [U18] | 3:1 | ||||
| 16. Ronde | 24.04.2022 | Santos Laguna [U18] | - | Club León [U18] | 2:3 |
Mexico