| 4. Ronde | 06.02.2022 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:1 |  |
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| 5. Ronde | 12.02.2022 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | ||||
| 8. Ronde | 02.03.2022 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 2:1 | |
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| 13. Ronde | 26.03.2022 | CF Monterrey [U20] | - | Santos Laguna [U20] | 1:2 |
Mexico