| 2. Ronde | 08.07.2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 7. Ronde | 06.08.2022 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 9. Ronde | 18.08.2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 11. Ronde | 28.08.2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | ||||
| 4. Ronde | 22.09.2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 17. Ronde | 02.10.2022 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 2:3 |
Mexico