| 4. Ronde | 29.01.2022 | CF Monterrey [] | - | Mazatlán FC [] | 3:2 | ||||
| 5. Ronde | 05.02.2022 | Mazatlán FC [] | - | UANL Tigres [] | 1:2 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 | ||||
| 13. Ronde | 02.04.2022 | Mazatlán FC [] | - | Club León [] | 0:3 | ||||
| 14. Ronde | 09.04.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 15. Ronde | 16.04.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 |
Mexico