| 1. Ronde | 12.01.2022 | Santos Laguna [U18] | - | UANL Tigres [U18] | 5:0 | ||||
| 2. Ronde | 16.01.2022 | Deportivo Toluca [U18] | - | Santos Laguna [U18] | 2:2 | ||||
| 3. Ronde | 23.01.2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 4. Ronde | 06.02.2022 | Atlas Guadalajara [U18] | - | Santos Laguna [U18] | 2:1 | ||||
| 5. Ronde | 12.02.2022 | Santos Laguna [U18] | - | CF América [U18] | 2:2 | ||||
| 6. Ronde | 18.02.2022 | FC Juárez [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 7. Ronde | 27.02.2022 | Cruz Azul [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 10. Ronde | 12.03.2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 11. Ronde | 18.03.2022 | Puebla FC [U18] | - | Santos Laguna [U18] | 2:2 | ||||
| 13. Ronde | 26.03.2022 | CF Monterrey [U18] | - | Santos Laguna [U18] | 1:2 |
Mexico