| 10. Ronde | 11.07.2021 | Santa Cruz | - | San Luis | 2:0 | ||||
| 11. Ronde | 15.07.2021 | Rangers | - | Santa Cruz | 1:3 | ||||
| 12. Ronde | 21.07.2021 | Santa Cruz | - | CD Magallanes | 2:0 |  |
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| 14. Ronde | 08.08.2021 | Cobreloa | - | Santa Cruz | 0:1 | ||||
| 15. Ronde | 15.08.2021 | Santa Cruz | - | San Marcos | 2:0 | ||||
| 17. Ronde | 28.08.2021 | Universidad de Concepción | - | Santa Cruz | 0:1 | ||||
| 18. Ronde | 01.09.2021 | Santa Cruz | - | Santiago Morning | 1:1 | ||||
| 19. Ronde | 05.09.2021 | Puerto Montt | - | Santa Cruz | 2:2 | ||||
| 20. Ronde | 14.09.2021 | Santa Cruz | - | Deportes Temuco | 1:0 |  |
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| 21. Ronde | 24.09.2021 | Coquimbo Unido | - | Santa Cruz | 0:0 | ||||
| 22. Ronde | 28.09.2021 | Santa Cruz | - | Unión San Felipe | 0:1 | ||||
| 23. Ronde | 03.10.2021 | Deportes Iquique | - | Santa Cruz | 6:1 | |
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| 24. Ronde | 08.10.2021 | Santa Cruz | - | Deportes Copiapó | 1:2 | |
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| 25. Ronde | 12.10.2021 | San Luis | - | Santa Cruz | 0:0 | ||||
| 26. Ronde | 19.10.2021 | Santa Cruz | - | Rangers | 1:0 | ||||
| 30. Ronde | 13.11.2021 | San Marcos | - | Santa Cruz | 0:0 |
Chili