| 1. Ronde | 12.02.2022 | CD Nacional [A-jun] | - | Vitória Setúbal [A-jun] | 4:0 | ||||
| 2. Ronde | 19.02.2022 | Vitória Setúbal [A-jun] | - | UD Vilafranquense [A-jun] | 2:2 |  |
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| 3. Ronde | 26.02.2022 | Vitória Setúbal [A-jun] | - | Amora FC [A-jun] | 1:0 | ||||
| 4. Ronde | 05.03.2022 | União Leiria [A-jun] | - | Vitória Setúbal [A-jun] | 2:2 | |
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| 5. Ronde | 12.03.2022 | Vitória Setúbal [A-jun] | - | SG Sacavenense [A-jun] | 3:1 | ||||
| 6. Ronde | 19.03.2022 | Académica de Coimbra [A-jun] | - | Vitória Setúbal [A-jun] | 1:0 | ||||
| 7. Ronde | 02.04.2022 | Vitória Setúbal [A-jun] | - | Os Belenenses [A-jun] | 3:1 | ||||
| 8. Ronde | 09.04.2022 | Vitória Setúbal [A-jun] | - | CD Nacional [A-jun] | 0:2 | ||||
| 9. Ronde | 16.04.2022 | UD Vilafranquense [A-jun] | - | Vitória Setúbal [A-jun] | 2:0 |
Portugal