| 2. Ronde | 16.01.2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 3. Ronde | 22.01.2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | ||||
| 10. Ronde | 06.03.2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Ronde | 15.03.2021 | Gallos Blancos | - | Atlético San Luis | 2:1 |  |
|||
| 12. Ronde | 21.03.2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | |
|||
| 13. Ronde | 04.04.2021 | CF Monterrey | - | Atlético San Luis | 2:0 | |
|||
| 14. Ronde | 10.04.2021 | FC Juárez | - | Atlético San Luis | 2:1 | |
|||
| 15. Ronde | 18.04.2021 | Atlético San Luis | - | Puebla FC | 1:4 |
Mexico