| 2. Ronde | 14.08.2021 | AS Vitré | - | EA Guingamp B | 0:4 | ||||
| 5. Ronde | 04.09.2021 | EA Guingamp B | - | Stade Plabennec | 2:1 |  |
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| 7. Ronde | 18.09.2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 9. Ronde | 09.10.2021 | EA Guingamp B | - | SM Caen B | 1:1 |  |
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| 10. Ronde | 23.10.2021 | EA Guingamp B | - | AS Poissy | 1:1 | ||||
| 11. Ronde | 06.11.2021 | C'Chartres Football | - | EA Guingamp B | 1:2 | ||||
| 15. Ronde | 15.01.2022 | SO Romorantin | - | EA Guingamp B | 2:3 | ||||
| 16. Ronde | 22.01.2022 | EA Guingamp B | - | AS Vitré | 0:5 | ||||
| 13. Ronde | 26.01.2022 | Vannes OC | - | EA Guingamp B | 2:0 | ||||
| 21. Ronde | 12.03.2022 | Blois Foot 41 | - | EA Guingamp B | 5:2 | ||||
| 24. Ronde | 09.04.2022 | AS Poissy | - | EA Guingamp B | 1:1 | ||||
| 25. Ronde | 16.04.2022 | EA Guingamp B | - | C'Chartres Football | 3:4 | |
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| 26. Ronde | 23.04.2022 | Châteaubriant Voltigeurs | - | EA Guingamp B | 0:2 | ||||
| 27. Ronde | 30.04.2022 | EA Guingamp B | - | Vannes OC | 1:0 | ||||
| 28. Ronde | 14.05.2022 | US Granvillaise | - | EA Guingamp B | 3:4 | ||||
| 29. Ronde | 21.05.2022 | EA Guingamp B | - | SO Romorantin | 1:2 | ||||
| 30. Ronde | 28.05.2022 | FC Rouen 1899 | - | EA Guingamp B | 2:1 |
Frankrijk