| 7. Ronde | 18.02.2021 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:4 | ||||
| 9. Ronde | 04.03.2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 11. Ronde | 14.03.2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 14. Ronde | 11.04.2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:0 |
Mexico