| 2. Ronde | 16.02.2022 | Mazatlán FC [U18] | - | CF América [U18] | 0:3 | ||||
| 6. Ronde | 20.02.2022 | Gallos Blancos [U18] | - | Mazatlán FC [U18] | 0:1 | ||||
| 7. Ronde | 24.02.2022 | CF Pachuca [U18] | - | Mazatlán FC [U18] | 3:1 | ||||
| 8. Ronde | 01.03.2022 | Mazatlán FC [U18] | - | Club Necaxa [U18] | 2:0 |  |
|||
| 10. Ronde | 11.03.2022 | CF Monterrey [U18] | - | Mazatlán FC [U18] | 2:2 | ||||
| 11. Ronde | 18.03.2022 | Mazatlán FC [U18] | - | Club León [U18] | 1:1 | ||||
| 9. Ronde | 26.03.2022 | Pumas UNAM [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U18] | - | Mazatlán FC [U18] | 3:1 | ||||
| 15. Ronde | 19.04.2022 | Mazatlán FC [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 16. Ronde | 22.04.2022 | FC Juárez [U18] | - | Mazatlán FC [U18] | 2:2 |
Mexico