| 1. Ronde | 06.08.2003 | Deportivo Guadalajara | - | Santos Laguna | 2:1 | ||||
| 2. Ronde | 10.08.2003 | Santos Laguna | - | Club Necaxa | 1:1 | ||||
| 3. Ronde | 17.08.2003 | Puebla FC | - | Santos Laguna | 1:1 |  |
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| 4. Ronde | 24.08.2003 | Santos Laguna | - | Pumas UNAM | 3:0 | ||||
| 5. Ronde | 30.08.2003 | Cruz Azul | - | Santos Laguna | 0:2 | |
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| 6. Ronde | 07.09.2003 | Santos Laguna | - | Veracruz (old) | 3:0 | ||||
| 7. Ronde | 14.09.2003 | UAG Tecos | - | Santos Laguna | 3:3 |  |
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| 8. Ronde | 20.09.2003 | Santos Laguna | - | CF Monterrey | 5:5 | ||||
| 9. Ronde | 24.09.2003 | CF América | - | Santos Laguna | 0:0 | ||||
| 10. Ronde | 28.09.2003 | Santos Laguna | - | Atlas Guadalajara | 3:2 | |
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| 11. Ronde | 04.10.2003 | Real San Luis | - | Santos Laguna | 3:0 | ||||
| 12. Ronde | 12.10.2003 | Santos Laguna | - | Club Irapuato | 5:0 | ||||
| 13. Ronde | 19.10.2003 | Santos Laguna | - | Atlante | 2:3 | ||||
| 14. Ronde | 23.10.2003 | Jaguares Chiapas | - | Santos Laguna | 1:1 | ||||
| 15. Ronde | 26.10.2003 | Santos Laguna | - | CF Pachuca | 1:2 | ||||
| 16. Ronde | 01.11.2003 | Monarcas Morelia | - | Santos Laguna | 2:4 | ||||
| 17. Ronde | 09.11.2003 | Santos Laguna | - | Gallos Blancos (old) | 2:1 | |
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| 18. Ronde | 15.11.2003 | UANL Tigres | - | Santos Laguna | 1:1 |
Chili