| 2. Ronde | 03.08.2021 | Atlético San Luis | - | Gallos Blancos | 1:1 | ||||
| 3. Ronde | 08.08.2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
| 4. Ronde | 13.08.2021 | Atlético San Luis | - | Club Necaxa | 0:2 | ||||
| 6. Ronde | 22.08.2021 | Atlético San Luis | - | Cruz Azul | 0:0 |  |
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| 7. Ronde | 28.08.2021 | Mazatlán FC | - | Atlético San Luis | 2:2 | ||||
| 8. Ronde | 11.09.2021 | Puebla FC | - | Atlético San Luis | 2:2 | ||||
| 9. Ronde | 17.09.2021 | Atlético San Luis | - | Club Tijuana | 4:1 |  |
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| 14. Ronde | 22.09.2021 | FC Juárez | - | Atlético San Luis | 1:0 | |
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| 10. Ronde | 26.09.2021 | Deportivo Toluca | - | Atlético San Luis | 1:2 | |
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| 11. Ronde | 30.09.2021 | Atlético San Luis | - | UANL Tigres | 0:3 | ||||
| 12. Ronde | 03.10.2021 | Club León | - | Atlético San Luis | 0:0 | ||||
| 5. Ronde | 04.11.2021 | CF Pachuca | - | Atlético San Luis | 0:0 |
Uruguay