| 8. Ronde | 28.02.2021 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 10. Ronde | 06.03.2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 |  |
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| 11. Ronde | 14.03.2021 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | ||||
| 14. Ronde | 10.04.2021 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 16. Ronde | 24.04.2021 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 3:2 |
Mexico