| 23. Ronde | 13.02.2022 | Cultural Leonesa | - | Unionistas CF | 0:1 | ||||
| 24. Ronde | 19.02.2022 | Extremadura UD | - | Cultural Leonesa | 1:3 |  |
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| 25. Ronde | 26.02.2022 | Cultural Leonesa | - | CD Tudelano | 3:1 |  |
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| 26. Ronde | 04.03.2022 | Rayo Majadahonda | - | Cultural Leonesa | 1:0 | ||||
| 22. Ronde | 09.03.2022 | Racing Santander | - | Cultural Leonesa | 4:0 | |
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| 27. Ronde | 13.03.2022 | Cultural Leonesa | - | SD Logroñés | 2:2 | ||||
| 28. Ronde | 19.03.2022 | Deportivo La Coruña | - | Cultural Leonesa | 2:1 | ||||
| 32. Ronde | 17.04.2022 | UD SS Reyes | - | Cultural Leonesa | 0:3 | |
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| 33. Ronde | 24.04.2022 | Real Valladolid B | - | Cultural Leonesa | 3:3 | ||||
| 34. Ronde | 01.05.2022 | Cultural Leonesa | - | Zamora CF | 0:0 | ||||
| 35. Ronde | 08.05.2022 | Celta de Vigo B | - | Cultural Leonesa | 5:3 | ||||
| 36. Ronde | 14.05.2022 | Cultural Leonesa | - | Inter de Madrid | 1:1 | |
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| 37. Ronde | 21.05.2022 | CF Talavera | - | Cultural Leonesa | 0:5 | ||||
| 38. Ronde | 28.05.2022 | Cultural Leonesa | - | UD Logroñés | 1:2 |
Panama