| 1. Ronde | 07.11.2021 | AO Egaleo | - | PAE Chania | 1:1 |  |
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| 2. Ronde | 14.11.2021 | PAE Chania | - | Irodotos | 0:0 | ||||
| 3. Ronde | 20.11.2021 | Levadiakos | - | PAE Chania | 1:1 | ||||
| 4. Ronde | 24.11.2021 | PAE Chania | - | AS Rhodos | 2:2 | ||||
| 5. Ronde | 28.11.2021 | AO Episkopi | - | PAE Chania | 1:1 | ||||
| 6. Ronde | 05.12.2021 | PAE Chania | - | AE Kifisias | 3:0 | ||||
| 7. Ronde | 12.12.2021 | AEK Athen II | - | PAE Chania | 1:0 | |
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| 8. Ronde | 15.12.2021 | PAE Chania | - | PS Kalamata | 1:2 | ||||
| 10. Ronde | 29.12.2021 | PAE Chania | - | AE Karaiskakis | 4:0 | ||||
| 13. Ronde | 12.01.2022 | Diagoras FC | - | PAE Chania | 2:2 | ||||
| 15. Ronde | 23.01.2022 | PAE Chania | - | APS Zakynthos | 5:1 |  |
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| 18. Ronde | 13.02.2022 | PAE Chania | - | AO Egaleo | 1:0 | ||||
| 19. Ronde | 16.02.2022 | Irodotos | - | PAE Chania | 2:2 | ||||
| 20. Ronde | 20.02.2022 | PAE Chania | - | Levadiakos | 3:1 | ||||
| 21. Ronde | 27.02.2022 | AS Rhodos | - | PAE Chania | 0:1 | ||||
| 22. Ronde | 06.03.2022 | PAE Chania | - | AO Episkopi | 1:0 | ||||
| 23. Ronde | 09.03.2022 | AE Kifisias | - | PAE Chania | 1:0 | ||||
| 24. Ronde | 12.03.2022 | PAE Chania | - | AEK Athen II | 2:1 | ||||
| 25. Ronde | 20.03.2022 | PS Kalamata | - | PAE Chania | 1:1 | ||||
| 33. Ronde | 27.04.2022 | PAE Chania | - | OFI Ierapetra | 2:0 | |
Guinea