| 1. Ronde | 04.04.2021 | Cobreloa | - | Barnechea | 1:2 | ||||
| 3. Ronde | 26.04.2021 | Cobreloa | - | Universidad de Concepción | 2:4 | ||||
| 4. Ronde | 04.05.2021 | Cobreloa | - | Coquimbo Unido | 1:1 |  |
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| 5. Ronde | 10.05.2021 | Unión San Felipe | - | Cobreloa | 0:0 | ||||
| 6. Ronde | 18.05.2021 | Cobreloa | - | Santiago Morning | 2:2 | ||||
| 8. Ronde | 30.05.2021 | Cobreloa | - | San Luis | 1:0 | ||||
| 11. Ronde | 15.07.2021 | Deportes Copiapó | - | Cobreloa | 0:0 | ||||
| 12. Ronde | 21.07.2021 | Cobreloa | - | Puerto Montt | 2:0 | ||||
| 13. Ronde | 31.07.2021 | Deportes Temuco | - | Cobreloa | 1:0 | ||||
| 19. Ronde | 06.09.2021 | Coquimbo Unido | - | Cobreloa | 2:1 |
Chili