| 18. Ronde | 12.02.2022 | C'Chartres Football | - | AS Vitré | 5:2 | ||||
| 19. Ronde | 19.02.2022 | AS Vitré | - | Châteaubriant Voltigeurs | 2:0 |  |
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| 20. Ronde | 05.03.2022 | Vannes OC | - | AS Vitré | 3:1 | ||||
| 21. Ronde | 12.03.2022 | AS Vitré | - | US Granvillaise | 1:1 | ||||
| 22. Ronde | 19.03.2022 | SO Romorantin | - | AS Vitré | 1:1 | |
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| 23. Ronde | 26.03.2022 | AS Vitré | - | FC Rouen 1899 | 2:2 | |
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| 24. Ronde | 09.04.2022 | AS Vitré | - | SM Caen B | 2:0 | ||||
| 25. Ronde | 16.04.2022 | FC Versailles | - | AS Vitré | 3:0 | ||||
| 26. Ronde | 23.04.2022 | AS Vitré | - | US Saint-Malo | 2:2 | ||||
| 27. Ronde | 30.04.2022 | Stade Plabennec | - | AS Vitré | 2:2 | ||||
| 28. Ronde | 14.05.2022 | AS Vitré | - | St-Pryvé St-Hilaire | 0:3 | ||||
| 29. Ronde | 21.05.2022 | Blois Foot 41 | - | AS Vitré | 5:4 | |
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| 30. Ronde | 28.05.2022 | AS Vitré | - | FC Lorient B | 0:5 |
Kameroen