| 1. Ronde | 07.02.2022 | Nacional | - | Deportivo Maldonado | 2:3 | ||||
| 5. Ronde | 13.03.2022 | Nacional | - | Montevideo City Torque | 1:1 |  |
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| 6. Ronde | 20.03.2022 | Montevideo Wanderers | - | Nacional | 2:2 | |
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| 7. Ronde | 02.04.2022 | Nacional | - | Plaza Colonia | 1:0 | |
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| 8. Ronde | 10.04.2022 | Boston River | - | Nacional | 0:6 | |
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| 9. Ronde | 17.04.2022 | Nacional | - | River Plate | 1:1 | |
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| 10. Ronde | 23.04.2022 | Cerro Largo | - | Nacional | 0:2 | |
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| 13. Ronde | 21.05.2022 | Nacional | - | Albion | 2:0 | ||||
| 14. Ronde | 29.05.2022 | Nacional | - | Cerrito | 3:0 | ||||
| 15. Ronde | 05.06.2022 | Danubio | - | Nacional | 2:1 | |
Uruguay