| 1. Ronde | 18.09.2021 | UANL Tigres [] | - | Atlético San Luis [] | 5:0 | ||||
| 2. Ronde | 25.09.2021 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 4:2 |  |
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| 3. Ronde | 02.10.2021 | Atlético San Luis [] | - | Santos Laguna [] | 1:1 | ||||
| 4. Ronde | 09.10.2021 | CF Monterrey [] | - | Atlético San Luis [] | 4:0 |
Mexico