| 2. Ronde | 19.09.2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 |  |
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| 3. Ronde | 22.09.2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
| 4. Ronde | 26.09.2021 | Asteras Tripolis | - | Olympiakos | 0:2 | ||||
| 5. Ronde | 02.10.2021 | Volos NFC | - | Asteras Tripolis | 2:1 | ||||
| 8. Ronde | 31.10.2021 | PAS Giannina | - | Asteras Tripolis | 1:1 | ||||
| 11. Ronde | 27.11.2021 | Asteras Tripolis | - | Atromitos | 6:2 | ||||
| 12. Ronde | 05.12.2021 | Aris Saloniki | - | Asteras Tripolis | 1:0 | ||||
| 14. Ronde | 14.12.2021 | Asteras Tripolis | - | Panetolikos | 1:0 | |
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| 16. Ronde | 04.01.2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 | |
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| 18. Ronde | 15.01.2022 | Asteras Tripolis | - | Volos NFC | 1:0 | |
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| 19. Ronde | 24.01.2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 | ||||
| 21. Ronde | 02.02.2022 | Asteras Tripolis | - | PAS Giannina | 2:0 | ||||
| 24. Ronde | 19.02.2022 | Atromitos | - | Asteras Tripolis | 2:0 | ||||
| 22. Ronde | 23.02.2022 | Lamia | - | Asteras Tripolis | 0:2 | ||||
| 17. Ronde | 02.03.2022 | Olympiakos | - | Asteras Tripolis | 5:1 |
Griekenland