| 1. Ronde | 06.11.2021 | AS Rhodos | - | Ergotelis | 1:0 | ||||
| 2. Ronde | 14.11.2021 | Asteras Vlachioti | - | AS Rhodos | 0:0 | ||||
| 4. Ronde | 24.11.2021 | PAE Chania | - | AS Rhodos | 2:2 | ||||
| 5. Ronde | 28.11.2021 | AS Rhodos | - | APS Zakynthos | 4:0 | ||||
| 8. Ronde | 15.12.2021 | AO Egaleo | - | AS Rhodos | 3:1 | ||||
| 10. Ronde | 29.12.2021 | Levadiakos | - | AS Rhodos | 5:0 | ||||
| 16. Ronde | 30.01.2022 | AS Rhodos | - | Panathinaikos II | 0:0 | ||||
| 7. Ronde | 02.02.2022 | AS Rhodos | - | GS Kallithea | 0:1 | ||||
| 17. Ronde | 06.02.2022 | AE Karaiskakis | - | AS Rhodos | 2:1 | ||||
| 15. Ronde | 09.02.2022 | PS Kalamata | - | AS Rhodos | 3:1 | ||||
| 18. Ronde | 13.02.2022 | Ergotelis | - | AS Rhodos | 0:1 | ||||
| 19. Ronde | 16.02.2022 | AS Rhodos | - | Asteras Vlachioti | 0:1 | ||||
| 20. Ronde | 20.02.2022 | Diagoras FC | - | AS Rhodos | 1:0 | ||||
| 12. Ronde | 23.02.2022 | AS Rhodos | - | AO Episkopi | 0:0 | ||||
| 21. Ronde | 27.02.2022 | AS Rhodos | - | PAE Chania | 0:1 | ||||
| 13. Ronde | 02.03.2022 | AE Kifisias | - | AS Rhodos | 1:0 | ||||
| 22. Ronde | 06.03.2022 | APS Zakynthos | - | AS Rhodos | 0:3 Toeg. | ||||
| 23. Ronde | 09.03.2022 | AS Rhodos | - | OFI Ierapetra | 1:2 | ||||
| 14. Ronde | 16.03.2022 | AS Rhodos | - | AEK Athen II | 1:0 | ||||
| 25. Ronde | 20.03.2022 | AS Rhodos | - | AO Egaleo | 0:1 |
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