| 1. Ronde | 07.08.2021 | SC Brühl | - | FC Zürich II | 2:5 |  |
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| 2. Ronde | 14.08.2021 | FC Breitenrain Bern | - | SC Brühl | 1:0 | ||||
| 5. Ronde | 04.09.2021 | SC Cham | - | SC Brühl | 0:1 | ||||
| 7. Ronde | 18.09.2021 | FC Bavois | - | SC Brühl | 1:3 | ||||
| 9. Ronde | 02.10.2021 | AC Bellinzona | - | SC Brühl | 2:1 | |
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| 10. Ronde | 09.10.2021 | SC Brühl | - | BSC Young Boys II | 0:3 | ||||
| 11. Ronde | 16.10.2021 | FC Chiasso | - | SC Brühl | 1:1 | ||||
| 12. Ronde | 23.10.2021 | SC Brühl | - | FC Biel/Bienne | 1:1 | ||||
| 13. Ronde | 30.10.2021 | FC Basel 1893 II | - | SC Brühl | 1:3 | ||||
| 14. Ronde | 06.11.2021 | SC Brühl | - | FC Sion II | 0:1 | |
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| 15. Ronde | 13.11.2021 | Etoile Carouge FC | - | SC Brühl | 2:1 | |
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| 18. Ronde | 04.12.2021 | FC Rapperswil-Jona | - | SC Brühl | 2:1 |
Zwitserland