| 1. Ronde | 20.02.2021 | Mushuc Runa | - | Aucas | 1:3 | ||||
| 2. Ronde | 28.02.2021 | 9 de Octubre | - | Mushuc Runa | 1:2 | ||||
| 3. Ronde | 06.03.2021 | Independiente del Valle | - | Mushuc Runa | 2:0 | ||||
| 4. Ronde | 14.03.2021 | Mushuc Runa | - | Manta | 4:2 | ||||
| 5. Ronde | 20.03.2021 | Mushuc Runa | - | Macará | 0:0 | ||||
| 6. Ronde | 03.04.2021 | LDU Quito | - | Mushuc Runa | 0:0 | ||||
| 7. Ronde | 08.04.2021 | Mushuc Runa | - | Olmedo | 4:0 | ||||
| 8. Ronde | 12.04.2021 | Orense SC | - | Mushuc Runa | 0:2 | ||||
| 9. Ronde | 17.04.2021 | Mushuc Runa | - | Barcelona | 2:2 | ||||
| 10. Ronde | 02.05.2021 | Técnico Universitario | - | Mushuc Runa | 1:3 |  |
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| 11. Ronde | 09.05.2021 | Mushuc Runa | - | Universidad Catolica | 2:6 | ||||
| 12. Ronde | 15.05.2021 | Deportivo Cuenca | - | Mushuc Runa | 1:2 | ||||
| 13. Ronde | 23.05.2021 | Mushuc Runa | - | Emelec | 1:2 | ||||
| 14. Ronde | 29.05.2021 | Guayaquil City | - | Mushuc Runa | 0:0 | ||||
| 15. Ronde | 17.07.2021 | Mushuc Runa | - | Delfín SC | 6:1 |
Chili