| 1. Ronde | 13.02.2022 | Rio Ave FC [A-jun] | - | GD Estoril [A-jun] | 0:1 | ||||
| 2. Ronde | 19.02.2022 | FC Alverca [A-jun] | - | Rio Ave FC [A-jun] | 1:0 | ||||
| 3. Ronde | 26.02.2022 | Rio Ave FC [A-jun] | - | Sporting Braga [A-jun] | 0:1 | ||||
| 4. Ronde | 05.03.2022 | FC Porto [A-jun] | - | Rio Ave FC [A-jun] | 1:1 | ||||
| 5. Ronde | 13.03.2022 | Rio Ave FC [A-jun] | - | SL Benfica [A-jun] | 3:3 |  |
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| 6. Ronde | 02.04.2022 | Sporting CP [A-jun] | - | Rio Ave FC [A-jun] | 3:1 | ||||
| 7. Ronde | 09.04.2022 | Rio Ave FC [A-jun] | - | Vitória Guimarães [A-jun] | 3:3 | ||||
| 8. Ronde | 16.04.2022 | GD Estoril [A-jun] | - | Rio Ave FC [A-jun] | 4:1 |  |
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| 9. Ronde | 23.04.2022 | Rio Ave FC [A-jun] | - | FC Alverca [A-jun] | 1:1 | ||||
| 10. Ronde | 30.04.2022 | Sporting Braga [A-jun] | - | Rio Ave FC [A-jun] | 2:1 | ||||
| 11. Ronde | 07.05.2022 | Rio Ave FC [A-jun] | - | FC Porto [A-jun] | 0:3 | ||||
| 12. Ronde | 13.05.2022 | SL Benfica [A-jun] | - | Rio Ave FC [A-jun] | 4:0 | ||||
| 13. Ronde | 21.05.2022 | Rio Ave FC [A-jun] | - | Sporting CP [A-jun] | 1:2 |
Portugal