| 17. Ronde | 29.08.2021 | Cobreloa | - | San Marcos | 0:3 Toeg. | ||||
| 18. Ronde | 02.09.2021 | Universidad de Concepción | - | Cobreloa | 0:0 | ||||
| 19. Ronde | 06.09.2021 | Coquimbo Unido | - | Cobreloa | 2:1 | ||||
| 20. Ronde | 16.09.2021 | Cobreloa | - | Unión San Felipe | 2:1 |  |
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| 21. Ronde | 22.09.2021 | Santiago Morning | - | Cobreloa | 2:1 | ||||
| 22. Ronde | 26.09.2021 | Cobreloa | - | Fernández Vial | 1:2 | ||||
| 23. Ronde | 02.10.2021 | San Luis | - | Cobreloa | 1:0 | ||||
| 24. Ronde | 06.10.2021 | Cobreloa | - | CD Magallanes | 2:1 | |
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| 25. Ronde | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 26. Ronde | 16.10.2021 | Cobreloa | - | Deportes Copiapó | 2:0 | |
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| 27. Ronde | 28.10.2021 | Puerto Montt | - | Cobreloa | 0:0 | ||||
| 28. Ronde | 02.11.2021 | Cobreloa | - | Deportes Temuco | 0:2 |  |
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| 29. Ronde | 07.11.2021 | Santa Cruz | - | Cobreloa | 2:2 | |
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| 30. Ronde | 13.11.2021 | Cobreloa | - | Rangers | 4:1 | |
Paraguay