| 3. Ronde | 08.08.2021 | Boca Juniors de Cali | - | Real Santander | 0:0 | ||||
| 6. Ronde | 28.08.2021 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 7. Ronde | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 |  |
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| 9. Ronde | 18.09.2021 | Bogotá FC | - | Real Santander | 1:1 | ||||
| 11. Ronde | 02.10.2021 | Orsomarso SC | - | Real Santander | 3:1 | ||||
| 12. Ronde | 09.10.2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 14. Ronde | 24.10.2021 | Real Santander | - | Fortaleza FC | 1:1 |
Colombia