| 4. Ronde | 14.08.2021 | Club León [U18] | - | Mazatlán FC [U18] | 1:1 |  |
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| 5. Ronde | 17.08.2021 | Deportivo Toluca [U18] | - | Mazatlán FC [U18] | 0:1 | ||||
| 6. Ronde | 20.08.2021 | Mazatlán FC [U18] | - | UANL Tigres [U18] | 0:4 | ||||
| 7. Ronde | 27.08.2021 | Mazatlán FC [U18] | - | Atlético San Luis [U18] | 5:1 | |
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| 8. Ronde | 11.09.2021 | CF América [U18] | - | Mazatlán FC [U18] | 2:1 | |
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| 9. Ronde | 18.09.2021 | Mazatlán FC [U18] | - | Pumas UNAM [U18] | 2:0 | |
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| 10. Ronde | 24.09.2021 | Club Tijuana [U18] | - | Mazatlán FC [U18] | 1:2 | ||||
| 11. Ronde | 28.09.2021 | Mazatlán FC [U18] | - | FC Juárez [U18] | 3:2 | |
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| 12. Ronde | 02.10.2021 | Santos Laguna [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 13. Ronde | 15.10.2021 | Mazatlán FC [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 14. Ronde | 19.10.2021 | Puebla FC [U18] | - | Mazatlán FC [U18] | 0:2 | ||||
| 17. Ronde | 05.11.2021 | Mazatlán FC [U18] | - | Deportivo Guadalajara [U18] | 2:1 |
Mexico