| 4. Ronde | 31.01.2021 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 5. Ronde | 06.02.2021 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 13. Ronde | 04.04.2021 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 5:2 | ||||
| 14. Ronde | 11.04.2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 15. Ronde | 18.04.2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | ||||
| 16. Ronde | 26.04.2021 | CF Pachuca [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 17. Ronde | 02.05.2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 |
Mexico