| 12. Ronde | 21.11.2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | ||||
| 13. Ronde | 28.11.2021 | Southampton FC U23 | - | West Bromwich Albion U23 | 3:1 | ||||
| 14. Ronde | 06.12.2021 | Stoke City U23 | - | Southampton FC U23 | 3:0 | ||||
| 15. Ronde | 17.12.2021 | Norwich City U23 | - | Southampton FC U23 | 4:3 | ||||
| 17. Ronde | 17.01.2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | ||||
| 18. Ronde | 23.01.2022 | Southampton FC U23 | - | Middlesbrough FC U23 | 1:0 | ||||
| 19. Ronde | 07.02.2022 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 | ||||
| 20. Ronde | 21.02.2022 | Southampton FC U23 | - | Birmingham City U23 | 2:3 | ||||
| 22. Ronde | 11.03.2022 | Aston Villa U23 | - | Southampton FC U23 | 2:2 | ||||
| 23. Ronde | 20.03.2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 | ||||
| 16. Ronde | 25.03.2022 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 | ||||
| 24. Ronde | 02.04.2022 | Burnley FC U23 | - | Southampton FC U23 | 2:1 | ||||
| 25. Ronde | 25.04.2022 | Newcastle United U23 | - | Southampton FC U23 | 2:4 | ||||
| 26. Ronde | 01.05.2022 | Southampton FC U23 | - | Sunderland AFC U23 | 1:0 |
Engeland