| 1. Ronde | 06.10.2021 | AC Horsens [B-jun] | - | Esbjerg fB [B-jun] | 2:1 | ||||
| 8. Ronde | 16.10.2021 | Silkeborg IF [B-jun] | - | Esbjerg fB [B-jun] | 1:0 | ||||
| 9. Ronde | 23.10.2021 | Esbjerg fB [B-jun] | - | FC København [B-jun] | 1:6 | ||||
| 7. Ronde | 26.10.2021 | Esbjerg fB [B-jun] | - | Randers SK Freja [B-jun] | 2:2 | ||||
| 10. Ronde | 30.10.2021 | Vejle BK [B-jun] | - | Esbjerg fB [B-jun] | 0:2 |  |
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| 12. Ronde | 20.11.2021 | Esbjerg fB [B-jun] | - | SønderjyskE [B-jun] | 1:3 | ||||
| 13. Ronde | 26.11.2021 | Odense BK [B-jun] | - | Esbjerg fB [B-jun] | 8:0 | ||||
| 15. Ronde | 05.03.2022 | Esbjerg fB [B-jun] | - | Vejle BK [B-jun] | 4:3 | ||||
| 16. Ronde | 12.03.2022 | Aarhus GF [B-jun] | - | Esbjerg fB [B-jun] | 4:1 | ||||
| 14. Ronde | 18.03.2022 | Brøndby IF [B-jun] | - | Esbjerg fB [B-jun] | 7:0 | ||||
| 17. Ronde | 02.04.2022 | Esbjerg fB [B-jun] | - | Lyngby BK [B-jun] | 3:3 | ||||
| 21. Ronde | 30.04.2022 | FC København [B-jun] | - | Esbjerg fB [B-jun] | 4:1 | ||||
| 24. Ronde | 31.05.2022 | Esbjerg fB [B-jun] | - | Silkeborg IF [B-jun] | 3:0 | ||||
| 25. Ronde | 10.06.2022 | SønderjyskE [B-jun] | - | Esbjerg fB [B-jun] | 5:6 |  |
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| 26. Ronde | 18.06.2022 | Esbjerg fB [B-jun] | - | Odense BK [B-jun] | 1:4 |
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