| 4. Ronde | 12.08.2018 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 5. Ronde | 19.08.2018 | Santos Laguna [U20] | - | UANL Tigres [U20] | 3:3 |  |
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| 6. Ronde | 23.08.2018 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 7. Ronde | 27.08.2018 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:0 | |
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| 8. Ronde | 02.09.2018 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 3:2 | ||||
| 3. Ronde | 08.09.2018 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 |  |
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| 10. Ronde | 23.09.2018 | Santos Laguna [U20] | - | CD Veracruz [U20] | 1:0 | ||||
| 11. Ronde | 29.09.2018 | Club Necaxa [U20] | - | Santos Laguna [U20] | 1:3 | ||||
| 12. Ronde | 05.10.2018 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 4:3 |  |
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| 2. Ronde | 10.10.2018 | Monarcas Morelia [U20] | - | Santos Laguna [U20] | 2:0 | ||||
| 13. Ronde | 20.10.2018 | CF Pachuca [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 14. Ronde | 26.10.2018 | Santos Laguna [U20] | - | CF Monterrey [U20] | 0:2 | ||||
| 15. Ronde | 04.11.2018 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:2 | |
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| 16. Ronde | 11.11.2018 | Santos Laguna [U20] | - | CF América [U20] | 0:0 | ||||
| 17. Ronde | 25.11.2018 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 4:0 |
Mexico