| 1. Ronde | 24.07.2021 | Deportivo Guadalajara [U18] | - | Atlético San Luis [U18] | 6:0 | ||||
| 2. Ronde | 02.08.2021 | Atlético San Luis [U18] | - | Gallos Blancos [U18] | 1:0 |  |
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| 3. Ronde | 08.08.2021 | Pumas UNAM [U18] | - | Atlético San Luis [U18] | 1:1 | ||||
| 4. Ronde | 12.08.2021 | Atlético San Luis [U18] | - | Club Necaxa [U18] | 3:3 | ||||
| 6. Ronde | 21.08.2021 | Atlético San Luis [U18] | - | Cruz Azul [U18] | 2:3 | ||||
| 7. Ronde | 27.08.2021 | Mazatlán FC [U18] | - | Atlético San Luis [U18] | 5:1 | ||||
| 13. Ronde | 16.10.2021 | Atlético San Luis [U18] | - | CF América [U18] | 1:1 | ||||
| 15. Ronde | 24.10.2021 | Atlético San Luis [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 16. Ronde | 31.10.2021 | Atlético San Luis [U18] | - | CF Monterrey [U18] | 3:1 | ||||
| 5. Ronde | 03.11.2021 | CF Pachuca [U18] | - | Atlético San Luis [U18] | 3:2 | ||||
| 17. Ronde | 07.11.2021 | Santos Laguna [U18] | - | Atlético San Luis [U18] | 6:1 |
Mexico