| 1. Ronde | 06.01.2022 | Atlético San Luis [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 3. Ronde | 20.01.2022 | Atlético San Luis [U18] | - | FC Juárez [U18] | 1:1 | ||||
| 4. Ronde | 05.02.2022 | CF América [U18] | - | Atlético San Luis [U18] | 3:1 | ||||
| 5. Ronde | 12.02.2022 | Atlético San Luis [U18] | - | Deportivo Toluca [U18] | 3:4 |  |
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| 6. Ronde | 19.02.2022 | UANL Tigres [U18] | - | Atlético San Luis [U18] | 0:1 | ||||
| 7. Ronde | 26.02.2022 | CF Monterrey [U18] | - | Atlético San Luis [U18] | 2:4 | ||||
| 8. Ronde | 02.03.2022 | Atlético San Luis [U18] | - | Deportivo Guadalajara [U18] | 1:2 | |
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| 10. Ronde | 13.03.2022 | Atlético San Luis [U18] | - | Puebla FC [U18] | 1:0 | ||||
| 11. Ronde | 17.03.2022 | Gallos Blancos [U18] | - | Atlético San Luis [U18] | 1:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U18] | - | Mazatlán FC [U18] | 3:1 | ||||
| 9. Ronde | 06.04.2022 | Club Tijuana [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 13. Ronde | 09.04.2022 | Atlético San Luis [U18] | - | Club León [U18] | 2:2 | ||||
| 14. Ronde | 15.04.2022 | Club Necaxa [U18] | - | Atlético San Luis [U18] | 1:2 | |
Mexico