| 1. Ronde | 07.08.2021 | CD Tondela [A-jun] | - | Vitória Guimarães [A-jun] | 2:1 | ||||
| 2. Ronde | 14.08.2021 | Vitória Guimarães [A-jun] | - | UD Oliveirense [A-jun] | 3:0 |  |
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| 3. Ronde | 21.08.2021 | Gil Vicente [A-jun] | - | Vitória Guimarães [A-jun] | 0:2 | ||||
| 4. Ronde | 28.08.2021 | Vitória Guimarães [A-jun] | - | Leixões SC [A-jun] | 2:1 | ||||
| 5. Ronde | 11.09.2021 | Vitória Guimarães [A-jun] | - | FC Vizela [A-jun] | 2:1 | |
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| 6. Ronde | 18.09.2021 | Paços de Ferreira [A-jun] | - | Vitória Guimarães [A-jun] | 3:3 | ||||
| 9. Ronde | 16.10.2021 | Vitória Guimarães [A-jun] | - | CD Feirense [A-jun] | 3:1 | ||||
| 13. Ronde | 20.11.2021 | UD Oliveirense [A-jun] | - | Vitória Guimarães [A-jun] | 2:7 | ||||
| 22. Ronde | 29.01.2022 | Rio Ave FC [A-jun] | - | Vitória Guimarães [A-jun] | 1:0 |
Portugal