| 15. Ronde | 16.08.2021 | Rangers | - | Cobreloa | 4:0 |  |
|||
| 16. Ronde | 24.08.2021 | Barnechea | - | Cobreloa | 1:1 | ||||
| 17. Ronde | 29.08.2021 | Cobreloa | - | San Marcos | 0:3 Toeg. | ||||
| 18. Ronde | 02.09.2021 | Universidad de Concepción | - | Cobreloa | 0:0 | ||||
| 19. Ronde | 06.09.2021 | Coquimbo Unido | - | Cobreloa | 2:1 |  |
|||
| 23. Ronde | 02.10.2021 | San Luis | - | Cobreloa | 1:0 | ||||
| 24. Ronde | 06.10.2021 | Cobreloa | - | CD Magallanes | 2:1 |
Chili