| 1. Ronde | 12.01.2003 | Santos Laguna | - | Atlas Guadalajara | 3:0 | ||||
| 2. Ronde | 19.01.2003 | Gallos Blancos (old) | - | Santos Laguna | 1:0 | ||||
| 3. Ronde | 26.01.2003 | Santos Laguna | - | Puebla FC | 1:1 |  |
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| 4. Ronde | 02.02.2003 | CF América | - | Santos Laguna | 0:1 | |
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| 5. Ronde | 09.02.2003 | Santos Laguna | - | Jaguares Chiapas | 1:2 | |
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| 6. Ronde | 15.02.2003 | Cruz Azul | - | Santos Laguna | 2:2 | |
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| 7. Ronde | 23.02.2003 | Santos Laguna | - | UAG Tecos | 3:1 | ||||
| 8. Ronde | 01.03.2003 | UANL Tigres | - | Santos Laguna | 2:2 | ||||
| 9. Ronde | 09.03.2003 | Santos Laguna | - | CF Pachuca | 2:0 | ||||
| 10. Ronde | 16.03.2003 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 11. Ronde | 23.03.2003 | Santos Laguna | - | Real San Luis | 2:0 | ||||
| 12. Ronde | 29.03.2003 | Atlético Cuernavaca | - | Santos Laguna | 2:3 | ||||
| 13. Ronde | 06.04.2003 | Club Necaxa | - | Santos Laguna | 0:1 | ||||
| 14. Ronde | 13.04.2003 | Santos Laguna | - | Atlante | 1:0 | ||||
| 15. Ronde | 19.04.2003 | Monarcas Morelia | - | Santos Laguna | 4:0 | ||||
| 16. Ronde | 27.04.2003 | Santos Laguna | - | Pumas UNAM | 4:1 | |
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| 17. Ronde | 03.05.2003 | Veracruz (old) | - | Santos Laguna | 1:0 | ||||
| 18. Ronde | 11.05.2003 | Santos Laguna | - | CF Monterrey | 1:2 |
Mexico