| 1. Ronde | 06.01.2022 | Atlético San Luis [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 2. Ronde | 15.01.2022 | Atlas Guadalajara [U18] | - | Atlético San Luis [U18] | 1:0 | ||||
| 3. Ronde | 20.01.2022 | Atlético San Luis [U18] | - | FC Juárez [U18] | 1:1 | ||||
| 4. Ronde | 05.02.2022 | CF América [U18] | - | Atlético San Luis [U18] | 3:1 | ||||
| 5. Ronde | 12.02.2022 | Atlético San Luis [U18] | - | Deportivo Toluca [U18] | 3:4 |  |
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| 12. Ronde | 01.04.2022 | Atlético San Luis [U18] | - | Mazatlán FC [U18] | 3:1 | |
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| 9. Ronde | 06.04.2022 | Club Tijuana [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 13. Ronde | 09.04.2022 | Atlético San Luis [U18] | - | Club León [U18] | 2:2 | ||||
| 14. Ronde | 15.04.2022 | Club Necaxa [U18] | - | Atlético San Luis [U18] | 1:2 | |
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| 15. Ronde | 20.04.2022 | Atlético San Luis [U18] | - | Pumas UNAM [U18] | 2:1 | |
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| 16. Ronde | 24.04.2022 | Cruz Azul [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 17. Ronde | 01.05.2022 | Atlético San Luis [U18] | - | Santos Laguna [U18] | 0:1 |
Mexico