| 15. Ronde | 09.10.2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 |  |
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| 16. Ronde | 16.10.2021 | Gimnasia de La Plata | - | Newell's Old Boys | 1:0 | ||||
| 17. Ronde | 21.10.2021 | Newell's Old Boys | - | Aldosivi | 0:0 | ||||
| 18. Ronde | 25.10.2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 | ||||
| 19. Ronde | 31.10.2021 | Newell's Old Boys | - | Independiente | 1:0 | ||||
| 20. Ronde | 08.11.2021 | Newell's Old Boys | - | Unión de Santa Fe | 1:0 | ||||
| 21. Ronde | 21.11.2021 | Arsenal de Sarandí | - | Newell's Old Boys | 3:1 | ||||
| 22. Ronde | 24.11.2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 | ||||
| 23. Ronde | 30.11.2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | ||||
| 24. Ronde | 07.12.2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Ronde | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
Paraguay