| 5. Ronde | 17.08.2021 | Club Necaxa [U18] | - | Pumas UNAM [U18] | 4:2 | ||||
| 6. Ronde | 22.08.2021 | Pumas UNAM [U18] | - | Puebla FC [U18] | 3:3 |  |
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| 7. Ronde | 29.08.2021 | Deportivo Toluca [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 8. Ronde | 12.09.2021 | Pumas UNAM [U18] | - | Deportivo Guadalajara [U18] | 1:1 | ||||
| 9. Ronde | 18.09.2021 | Mazatlán FC [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 12. Ronde | 03.10.2021 | CF América [U18] | - | Pumas UNAM [U18] | 1:0 | |
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| 13. Ronde | 17.10.2021 | Pumas UNAM [U18] | - | FC Juárez [U18] | 2:0 |  |
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| 14. Ronde | 20.10.2021 | Club León [U18] | - | Pumas UNAM [U18] | 2:1 | |
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| 15. Ronde | 24.10.2021 | Pumas UNAM [U18] | - | Club Tijuana [U18] | 2:2 | ||||
| 11. Ronde | 04.11.2021 | Pumas UNAM [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 17. Ronde | 07.11.2021 | Pumas UNAM [U18] | - | Cruz Azul [U18] | 2:2 | |
Mexico