| 1. Ronde | 08.01.2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 3:2 |  |
|||
| 2. Ronde | 15.01.2022 | Club Tijuana [U18] | - | Club León [U18] | 1:2 | ||||
| 4. Ronde | 05.02.2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 |  |
|||
| 5. Ronde | 11.02.2022 | Mazatlán FC [U18] | - | Club Tijuana [U18] | 0:2 | ||||
| 6. Ronde | 18.02.2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 3:2 | |
|
||
| 7. Ronde | 25.02.2022 | Club Tijuana [U18] | - | Atlas Guadalajara [U18] | 3:3 | ||||
| 8. Ronde | 01.03.2022 | Deportivo Toluca [U18] | - | Club Tijuana [U18] | 1:1 | |
|||
| 10. Ronde | 12.03.2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 11. Ronde | 18.03.2022 | Club Tijuana [U18] | - | FC Juárez [U18] | 3:2 | ||||
| 12. Ronde | 03.04.2022 | UANL Tigres [U18] | - | Club Tijuana [U18] | 2:0 | ||||
| 9. Ronde | 06.04.2022 | Club Tijuana [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 13. Ronde | 11.04.2022 | CF Pachuca [U18] | - | Club Tijuana [U18] | 1:2 | ||||
| 14. Ronde | 15.04.2022 | Club Tijuana [U18] | - | CF América [U18] | 2:0 |
Mexico