| 2. Ronde | 25.01.2004 | Club Necaxa | - | Santos Laguna | 2:2 |  |
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| 3. Ronde | 01.02.2004 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 6. Ronde | 21.02.2004 | Veracruz (old) | - | Santos Laguna | 2:1 | ||||
| 7. Ronde | 26.02.2004 | Santos Laguna | - | UAG Tecos | 2:1 | ||||
| 8. Ronde | 29.02.2004 | CF Monterrey | - | Santos Laguna | 2:1 | ||||
| 5. Ronde | 04.03.2004 | Santos Laguna | - | Cruz Azul | 3:2 | ||||
| 9. Ronde | 07.03.2004 | Santos Laguna | - | CF América | 0:1 | ||||
| 10. Ronde | 14.03.2004 | Atlas Guadalajara | - | Santos Laguna | 2:0 | ||||
| 11. Ronde | 21.03.2004 | Santos Laguna | - | Real San Luis | 2:0 | ||||
| 12. Ronde | 28.03.2004 | Club Irapuato | - | Santos Laguna | 0:3 | ||||
| 13. Ronde | 04.04.2004 | Atlante | - | Santos Laguna | 2:1 | |
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| 14. Ronde | 11.04.2004 | Santos Laguna | - | Jaguares Chiapas | 1:1 | ||||
| 15. Ronde | 18.04.2004 | CF Pachuca | - | Santos Laguna | 2:2 | ||||
| 16. Ronde | 25.04.2004 | Santos Laguna | - | Monarcas Morelia | 6:0 | ||||
| 18. Ronde | 08.05.2004 | Santos Laguna | - | UANL Tigres | 2:3 | ||||
| 19. Ronde | 16.05.2004 | Deportivo Toluca | - | Santos Laguna | 4:1 |
Mexico