| 3. Ronde | 08.08.2021 | Pumas UNAM [U20] | - | Atlético San Luis [U20] | 5:3 | ||||
| 4. Ronde | 14.08.2021 | Pumas UNAM [U20] | - | Gallos Blancos [U20] | 1:4 |  |
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| 5. Ronde | 17.08.2021 | Club Necaxa [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 6. Ronde | 22.08.2021 | Pumas UNAM [U20] | - | Puebla FC [U20] | 1:3 | |
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| 7. Ronde | 29.08.2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 |  |
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| 9. Ronde | 18.09.2021 | Mazatlán FC [U20] | - | Pumas UNAM [U20] | 2:1 |  |
Mexico