| 1. Ronde | 09.01.2022 | Deportivo Guadalajara [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 3. Ronde | 21.01.2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 |  |
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| 4. Ronde | 06.02.2022 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 5. Ronde | 11.02.2022 | Mazatlán FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
| 6. Ronde | 20.02.2022 | Gallos Blancos [U20] | - | Mazatlán FC [U20] | 0:0 | ||||
| 7. Ronde | 24.02.2022 | CF Pachuca [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 10. Ronde | 11.03.2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:3 | ||||
| 14. Ronde | 14.04.2022 | Atlas Guadalajara [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 16. Ronde | 22.04.2022 | FC Juárez [U20] | - | Mazatlán FC [U20] | 3:0 |
Mexico