| 2. Ronde | 01.08.2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 4. Ronde | 14.08.2021 | Cruz Azul [U20] | - | Deportivo Toluca [U20] | 2:2 |  |
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| 5. Ronde | 18.08.2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 6. Ronde | 21.08.2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 9. Ronde | 19.09.2021 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 1:1 | ||||
| 10. Ronde | 24.09.2021 | Puebla FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 12. Ronde | 04.10.2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 13. Ronde | 16.10.2021 | Cruz Azul [U20] | - | UANL Tigres [U20] | 1:0 | ||||
| 14. Ronde | 19.10.2021 | Atlas Guadalajara [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 16. Ronde | 31.10.2021 | Cruz Azul [U20] | - | CF América [U20] | 1:1 | ||||
| 17. Ronde | 07.11.2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 1:2 | |
Mexico