| 1. Ronde | 25.07.2021 | Lokomotiv Plovdiv | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 2. Ronde | 31.07.2021 | PFC Ludogorets Razgrad | - | CSKA 1948 Sofia | 3:0 | ||||
| 5. Ronde | 21.08.2021 | PFC Ludogorets Razgrad | - | Lokomotiv Sofia | 5:0 |  |
|||
| 6. Ronde | 29.08.2021 | Pirin Blagoevgrad | - | PFC Ludogorets Razgrad | 1:3 | |
 |
||
| 7. Ronde | 11.09.2021 | PFC Ludogorets Razgrad | - | Cherno More Varna | 2:0 | ||||
| 8. Ronde | 19.09.2021 | Slavia Sofia | - | PFC Ludogorets Razgrad | 1:0 | ||||
| 9. Ronde | 26.09.2021 | PFC Ludogorets Razgrad | - | Botev Vratsa | 3:1 | ||||
| 11. Ronde | 16.10.2021 | PFC Ludogorets Razgrad | - | Tsarsko Selo Sofia | 4:0 | |
|||
| 12. Ronde | 25.10.2021 | Botev Plovdiv | - | PFC Ludogorets Razgrad | 1:3 | ||||
| 13. Ronde | 31.10.2021 | PFC Ludogorets Razgrad | - | PFC Beroe | 2:0 |
Portugal