| 2. Ronde | 16.01.2021 | Cruz Azul [U20] | - | Puebla FC [U20] | 1:0 | ||||
| 4. Ronde | 30.01.2021 | Cruz Azul [U20] | - | Gallos Blancos [U20] | 0:0 | ||||
| 5. Ronde | 05.02.2021 | Club Necaxa [U20] | - | Cruz Azul [U20] | 0:1 |  |
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| 6. Ronde | 13.02.2021 | UANL Tigres [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 8. Ronde | 27.02.2021 | Club León [U20] | - | Cruz Azul [U20] | 1:2 | |
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| 9. Ronde | 03.03.2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 2:2 | |
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| 10. Ronde | 07.03.2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 11. Ronde | 13.03.2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 1:3 |  |
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| 1. Ronde | 26.03.2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 3:1 | ||||
| 13. Ronde | 02.04.2021 | FC Juárez [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 3. Ronde | 07.04.2021 | CF Pachuca [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 15. Ronde | 17.04.2021 | CF América [U20] | - | Cruz Azul [U20] | 4:1 | ||||
| 16. Ronde | 24.04.2021 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 0:1 | |
Mexico