| 3. Ronde | 23.01.2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 | ||||
| 4. Ronde | 06.02.2022 | Atlas Guadalajara [U18] | - | Santos Laguna [U18] | 2:1 | ||||
| 12. Ronde | 03.04.2022 | Santos Laguna [U18] | - | CF Pachuca [U18] | 3:1 | ||||
| 14. Ronde | 16.04.2022 | Santos Laguna [U18] | - | Gallos Blancos [U18] | 3:0 |  |
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| 15. Ronde | 19.04.2022 | Mazatlán FC [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 16. Ronde | 24.04.2022 | Santos Laguna [U18] | - | Club León [U18] | 2:3 | ||||
| 17. Ronde | 01.05.2022 | Atlético San Luis [U18] | - | Santos Laguna [U18] | 0:1 |
Mexico